RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-221
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
Mtt assay; qRT-PCR; etc.
Target
Hmga2
Pathway
NA
PubMed ID
Title
MiR 221 targets HMGA2 to inhibit bleomycin induced pulmonary fibrosis by regulating TGF B1/Smad3-induced EMT
Year
2016
Function
The expression of miR 221 was inhibited in both IPF tissues and pulmonary cells whereas mRNA and protein expression of HMGA2 were increased. MiR 221 targets HMGA2 to inhibit BLM induced pulmonary fibrosis through the TGF B1/Smad3 signaling pathway.